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The duo were retested after their initial Covid-19 results proved inconclusive.
He is the third Spurs player to score a double century of goals after Jimmy Greaves and Bobby Smith.
Maddison scored on his European debut against Zorya Luhansk.
The 25-year-old Raheem Sterling said he wanted to create something “humongous” for the people he was helping.
Tampa Bay's Ryan Succop made four field goals with Ronald Jones the only Buccaneer to find the end zone on an eight-metre run, while the Patriots scored a TD in each half.