World No. 1 Djokovic missed the first calendar-year Slam since 1969 at the final hurdle Sunday, losing to Russia's second-ranked Daniil Medvedev 6-4, 6-4, 6-4 in Arthur Ashe Stadium.
It will be a life-changing moment for Raducanu, who sat her A-Levels only three months ago.
British 18-year-old qualifier Emma Raducanu and Canadian 19-year-old Leylah Fernandez completed astonishing runs to their historic first Grand Slam final on Thursday at the US Open.
Djokovic and Berrettini had met only three times previously but two held in this year when the stakes were at their highest the Wimbledon final and French Open quarters with the world number one winning both times in 4 sets.
Medvedev into third straight US Open semi. The Russian dropped his first set of the fortnight, but only after winning a bagel second stanza against qualifier Botic van de Zandschulp.
Raducanu was an unknown wildcard when she arrived at Wimbledon earlier this year, ranked a lowly 338 in the world and with just one WTA Tour-level match under her belt
Alcaraz, who is 18 years and four months old, is eight days younger than Andre Agassi when the American reached the 1988 U.S. Open quarter-finals and semi-finals, according to U.S. Open stats.
18-year-old Leylah Fernandez of Canada dismissed defending champion Naomi Osaka on the very same court, 5-7, 7-6, 6-4, to break through of the US Open Round of 16 at Arthur Ashe Stadium.
Naomi Osaka has progressed to the third round of the US Open via walkover from Olga Danilovic
The Greek government on Thursday criticised tennis star Stefanos Tsitsipas for insisting he would only get a coronavirus vaccination if it became mandatory.